Danish Pharmacovigilance Update, 18 October 2012

In this issue of Danish Pharmacovigilance Update:

• Risk of developing hepatotoxicity in patients undergoing treatment with agomelatine (Valdoxan®) (front page)
• Cases of lactic acidosis in patients undergoing treatment with metformin for the treatment of type 2 diabetes (pp 2-3)
• Use of MAOIs (monoamino oxidase inhibitors) and other antidepressants (p 4)
• Restricted indications for trimetazidine (Vastarel®) (p 5)
• Report of development of jaundice following initiation of treatment with medicines containing amoxicillin plus clavulanic acid (p 6)
• Childhood vaccinations and adverse reactions in the second quarter of 2012 (pp 7-9)
• Information on the safety of HPV vaccines (p 10)
• Doctors in Denmark follow new recommendations for contraceptive pills (p 10)